Homocysteine lowering, B vitamins, and cognitive aging
نویسندگان
چکیده
منابع مشابه
High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study.
BACKGROUND Elevated homocysteine concentrations may contribute to cognitive impairment. Most elevations in homocysteine result from inadequate folate, vitamin B-12, or vitamin B-6 intake. It is not clear whether the observed associations between homocysteine and cognitive measures are causal or whether they are due to homocysteine, to independent actions of the B vitamins, or to both. OBJECTI...
متن کاملEffects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals12345
BACKGROUND Elevated plasma homocysteine is a risk factor for Alzheimer disease, but the relevance of homocysteine lowering to slow the rate of cognitive aging is uncertain. OBJECTIVE The aim was to assess the effects of treatment with B vitamins compared with placebo, when administered for several years, on composite domains of cognitive function, global cognitive function, and cognitive agin...
متن کاملEffects of homocysteine lowering with B vitamins on cognitive aging: meta-analysis of 11 trials with cognitive data on 22,000 individuals
Background: Elevated plasma homocysteine is a risk factor for Alzheimer disease, but the relevance of homocysteine lowering to slow the rate of cognitive aging is uncertain. Objective: The aim was to assess the effects of treatment with B vitamins compared with placebo, when administered for several years, on composite domains of cognitive function, global cognitive function, and cognitive agin...
متن کاملHomocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease
The Writing Group (Eva Lonn, M.D., and Salim Yusuf, D.Phil., M.B., B.S., Population Health Research Institute, McMaster University, and the Department of Medicine, Division of Cardiology, Hamilton Health Sciences, Hamilton, Ont.; Malcolm J. Arnold, M.D., Department of Medicine, Division of Cardiology, University of Western Ontario, London; Patrick Sheridan, M.Sc., Janice Pogue, M.Sc., and Mary ...
متن کامل[Homocysteine lowering with folic acid and B vitamins in vascular disease].
BACKGROUND In observational studies, lower homocysteine levels are associated with lower rates of coronary heart disease and stroke. Folic acid and vitamins B6 and B12 lower homocysteine levels. We assessed whether supplementation reduced the risk of major cardiovascular events in patients with vascular disease. METHODS We randomly assigned 5522 patients 55 years of age or older who had vascu...
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ژورنال
عنوان ژورنال: The American Journal of Clinical Nutrition
سال: 2015
ISSN: 0002-9165,1938-3207
DOI: 10.3945/ajcn.114.098467